Liverpool travel to Southampton on Sunday as they look to go eight points clear at the summit.
The recent meetings and the form of both suggest the Reds are clear favorites to do so but Arne Slot will know how difficult Russell Martin's possession-based Saints side can be.
Here we look at the last few meetings between the two sides.
Liverpool 3-0 Southampton - Fa Cup - 28th February 2024
The most recent meeting was in last season's Fa Cup where Klopp's kids really came of age. Young Lewis Koumas lit up his debut with a reverse finish in the first half but the second half began to Jayden Danns.
The teenage forward had already lifted a superb dinked finish over Joe Lumley before he gobbled up a rebound to get his brace late on.
Other youngsters who impressed included James McConnell, Bobby Clark and then sixteen year old Trey Nyoni.
Southampton 4-4 Liverpool - Premier League - 28th May 2023
An absolutely bonkers final day saw already relegated Southampton threaten a shock victory before a late comeback salvaged a draw.
Diogo Jota and Roberto Firmino scored early in what looked like a routine victory for the Reds before Southampton came roaring back.
James Ward-Prowse brought the home side back in before a Kam Sulemana double either side of the break completely turned the tide.
Adam Armstrong added an incredible fourth which looked to had put the contest to bed before Cody Gakpo and Jota scored within moments of each other.
Liverpool 3-1 Southampton - Premier League - 12th November 2022.
The last league meeting at Anfield between the two sides saw all the action come in a frantic first half. Roberto Firmino and Che Adams both scored within the opening ten minutes before Liverpool turned the screw towards the end of the half.
Darwin Nunez smashed home a quickfire brace and he slotted two clever passes into either corner before a quiet second half saw Liverpool come away with all three points.
Southampton 1-2 Liverpool - Premier League - 17th May 2022
Liverpool's last league win on this ground came towards the tail end of the 2021-22 season.
Nathan Redmond gave the home side another early lead before a pair of unlikely goal scorers turned the game on it's head.
Takumi Minamino collected neatly from Diogo Jota before lashing home the equaliser before big Joel Matip planted a header home to send Liverpool home happy.
Liverpool 4-0 Southampton - Premier League - 27th November 2021.
Liverpool ran riot in this victory over the Saints as the recent champions continued their fine form. A blistering first half saw the Reds go three up into the break.
Diogo Jota haunted the Saints again with a quickfire brace before Thiago thumped home late in the half.
The damage was done before the second half but Liverpool would add another goal and it was a former Saint who got it. Virgil van Dijk powered home a low finish for four.